![]() The disease manifests with a triad of clinical signs, including uncontrollable movements (chorea) later replaced by akinesia, psychiatric symptoms such as depression, and cognitive impairment culminating in dementia ( Tabrizi et al., 2020). Huntington’s disease (HD) is a hereditary movement disorder that typically starts in midlife and is inevitably lethal within 10–20 years after onset. Taken together, our findings point to differential molecular changes in cortical interneuron types of HD mice. In contrast to the R6/2 model, heterozygous zQ175DN knock-in HD mice do not show any significant histological changes in cortical cell types at the age of 12 months, apart from the presence of mHTT inclusions, which are abundant in pyramidal neurons and rare in interneurons. Furthermore, we demonstrate progressive accumulation of mutant Huntingtin (mHTT) inclusion bodies in interneurons, which occurs faster in SST and VIP compared to PV cells. We also observe a reduction in cell body size for all three interneuron populations. However, genetic labeling reveals unchanged cell numbers for all the interneuron types, pointing to molecular marker loss in the absence of cell death. In R6/2 mice, we find a selective reduction in SST and VIP, but not PV-positive cells. Here, we use a combination of immunostaining and genetic tracing to investigate histological changes in three major cortical interneuron types - parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP) interneurons - in the R6/2 and zQ175DN mouse models of HD. In the cortex, glutamatergic pyramidal neurons are known to be severely affected by the disease, but the involvement of GABAergic interneurons remains unclear. HD causes neurodegeneration particularly in the basal ganglia and neocortex. Huntington’s disease (HD) is a debilitating hereditary motor disorder caused by an expansion of the CAG triplet repeat in the Huntingtin gene. 3Center for Anatomy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.2Molecular Neurodegeneration Group, Max Planck Institute for Biological Intelligence, Martinsried, Germany. ![]() 1Department of Molecules–Signaling–Development, Max Planck Institute for Biological Intelligence, Martinsried, Germany.Kerstin Voelkl 1,2 Elena Katharina Schulz-Trieglaff 1 Rüdiger Klein 1 Irina Dudanova 1,2,3* ![]()
0 Comments
![]() ![]() Works with families to minimize language, cultural, emotional, and logistical barriers to partnership (e.g., provides translated materials asks families about convenient forms of communication).Ensure classroom environment and communication with families are free from biases (e.g., classroom and communication are welcoming to multiple cultures, backgrounds, and home languages).Builds relationships with families by connecting informally (e.g., relates a positive story via phone call).Shows respect in communications with families (e.g., by monitoring body language and tone of voice and addressing parents in respectful terms).Opportunities to engage families outside of the regular school day.Ī log of activities, opportunities or communications made for family engagement must be on file at each KIPP Texas Public School campus. Allowing family members, the opportunity for involvement in decision making about their own child and about their child’s early childhood program and.Classroom visits and options for parents and families to participate in classroom activities.Formal and informal parent/teacher conferences.The following are examples of meaningful opportunities for families to be engaged in their child’s education: Strategies should be designed to develop partnerships with families and build reciprocal relationships that promote shared decision making. Each KIPP Texas Public School shall develop a comprehensive plan for family engagement to implement strategies in all PK classrooms. KIPP Texas Public Schools Pre-Kindergarten (“PK”) classrooms shall provide meaningful opportunities for families to be engaged in their child’s education. *Schools will verify a student’s eligibility during the enrollment (NTK students) and re-enrollment process (returning students) for Pre-K. *For military duty, families will need to provide a military ID or letter from the VA stating a service-connected disability for those injured while on active duty. This automatic qualification does not apply to New-to-KIPP (NTK) Pre-K4 students. *Please note that under Senate Bill 1679, any KIPP Texas Pre-K3 student who qualifies for free Pre-K3 will automatically be eligible for free Pre-K4. To be eligible in a tuition-based Pre-K class, a child must be 3 (Pre-K3) or 4(Pre-K4) years old by September 1 of the current school year AND: are the child of a person who received the Star of Texas Award as a peace officer, a firefighter or an emergency medical first responder.who have been in the care of the Department of Family and Protective Services, or.a child of a parent who was injured or killed during active military duty, or.qualify for free and reduced-cost lunch, or.To be eligible in a free Pre-K class, a child must be 3 (Pre-K3) or 4 (Pre-K4) years old by September 1 of the current school year AND: There are certain eligibility requirements to qualify for free Pre-K. ![]() ![]() ![]() For frying food without carbonising it, this is essential. Wind permitting, you can turn it right down to an ultra-low simmer. What if your camp cookery aspirations go beyond simply vapourising water as loudly as possible? Well unlike your typical system stove, output on the Pocket Rocket 2 is fully adjustable. Except perhaps for winter or high mountain use, my money (and it's a lot less money too) would be on the Pocket Rocket 2. Crucially, it's a hell of a lot smaller and lighter than a stove system, and also arguably more versatile, in that you can use it with any pot, kettle or frying pan. An all-in-one stove system such as the MSR Windburner may be marginally faster, more windproof and more fuel efficient, but bearing in mind the inherent limitations of its simple screw-on design, the Pocket Rocket 2 still performs very respectably indeed. For quick brews, noodles, soup and dehydrated meals, boiling lots of water as fast as possible is clearly an advantage. If you just want to boil the living daylights out of something, I don't think you'll find a more effective compact stove than this. If you're doing that, then perhaps an inbuilt ignition would be more or less redundant anyway.įire it up full tilt, and you've basically got a pocket blowtorch. ![]() In any case I would not trust a single ignition source, and always carry a couple of cigarette lighters when camping (at least if I remember to pack them). Some will consider this a mixed blessing, but it clearly means less weight and less to potentially go wrong. As I've said, you don't get an inbuilt ignition with the Pocket Rocket 2 instead MSR have gone for simplicity and reliability. ![]() The large control knob, meanwhile, is easy to operate with gloves or cold fingers. Once folded out, the pan supports are wide enough to fit even quite a big pan. That's the price you pay for compactness and simplicity - and for most of my camping and bivvying trips it's a price I'm personally happy to pay for the convenience of a small gas stove. of fuel 2 liters Country of Origin Made in Koreaīest Price Found: £ 25.As ever with canister-top stoves, the small base and top-heavy balance do mean that you have to search out flat enough ground, and take a bit of extra care when cooking. 60 minutes Boil time (MSR IsoPro), 1 liter 3.5 minutes Water boiled (MSR IsoPro) per 227 g canister 16 liters Water boiled (MSR IsoPro) per 1 oz. Minimum Weight 3 oz 85 g Packaged Weight 4.2 oz 119 g Burn time (MSR IsoPro) per 227 g 8 oz. *Flame Protection Tri sectional WindclipTM wind shield protects flame and boosts efficiency. *Full Flame Control Glove friendly controls allow precise flame adjustment, from a simmer to a boil. *High Heat Output Boils 1 liter of water in under 3.5 minutes. *Simple Operation No need for priming, pressurizing, or maintenance. (85 g), with palm sized dimensions 4 x 2 x 2 in. *Ultralight, Ultra Compact Weighs just 3 oz. The PocketRocket stoves diminutive size is also the foundation of a solid emergency kit for home or trail. Precision flame control goes from torch to simmer while our Wind ClipTM wind shield boosts efficiency in breezy conditions. Barely noticeable in your pack, it delivers impressively in camp. Prices were last updated on Tuesday, November 28, 2023*. MSR Pocket Rocket Stove The PocketRocket backpacking stove provides full cooking function in an incredibly efficient form. With the lowest price over the last 30 days being £25.94. The average lowest price for the last 30 days was £25.94. MSR Pocket Rocket Camping Stove prices range from £25.94 to £33.99 potentially saving you £8.05 when you compare prices through easybuytent. Compare prices across 8 in stock retailers. ![]() ![]() Each zone is separated by 10 oF and the map was updated in 2012. And these are averages, here in zone 8B ('A' represents the colder half of a zone and 'B' represents the warmer half of the zone and they are separated by about 5 oF) we have seen single digits but that is the exception but should be noted by the daring gardener. ![]() USDA Cold Hardiness Zones were established to give gardeners, horticulturists, farmers, nurseries, and landscape architects a universal way to describe where a plant will survive with regard to average winter lows for a region. ![]() Under poor growing conditions plants may be slightly to significantly smaller, whereas excellent growing conditions can produce larger more vigorous plants. Parentheses are used to indicate that the plant can potentially reach that dimension, although the sizes outside of the parentheses tend to be more typical. Feet are represented by a single quote and inches by a double quote. This is the average expected mature height by width in feet or inches. Grows To: 10-20'H+ but easily maintained on a sturdy 6'H fence or 8-12'H post Smarty Plants response for more detailed info on the plant's toxicity at: Interestingly, the strychnine-like toxins are considered to provide some protection from disease for native bee species, like Mason bees ( Osmia spp.), even in what is considered to be toxic doses. *Note: Its nectar is considered toxic to honeybees and honey made from the flowers may be toxic to humans and animals. This plant is the state flower of South Carolina. Jessamine is an older English equivalent of and is also the French word for Jasmine. Songbirds will often use the dense canopy of wiry vines of the Carolina Yellow Jasmine for nesting. Its fragrance is enough to stop you in your tracks on an evening stroll! A Pennsylvania Horticulture Society Gold Medal Award Winner! Tough and easy as well as drought, deer, and rabbit resistant. Although, it is shade tolerant it doesn't flower as profusely. Provide Carolina Yellow Jasmine with a full sun to mostly sunny site in an average to well-drained, fertile soil for optimum growth and to maximize flowering. The species, Gelsemium sempervirens, is native to the southeastern US, but, Margarita was selected by Don Jacobs of Eco Gardens in Decatur, Georgia. Margarita Carolina Yellow Jessamine, with larger flowers, more flowers, and improved cold hardiness over the species surviving -25 oF at North Creek Nurseries in Landenberg, PA. This a native, twining, evergreen to semi-evergreen vine with glossy, dark green, narrow foliage that can climb up to 20' high but is just as happy on a 6' fence or other sturdy support. *It is not a suitable nectar plant for honeybees. Masses of primrose yellow, 1" long trumpets herald the coming of spring and have a strong Jasmine-like fragrance that is produced in early evening and at night suggesting that they are pollinated by hummingbird or sphinx moths as well as by native bees, butterflies, and hummingbirds. Yellow Foliage/Stems or Marked with Yellow.White Foliage/Stems or Marked with White.Silver or Gray Foliage/Stems or Marked with Gray or Silver.Purple Foliage/Stems or Marked with Purple.Orange Foliage/Stems or Marked with Orange.Maroon, Burgundy, or Purplish-Red Foliage/Stems.Chartreuse Foliage/Stems or Marked with Chartreuse.Black Foliage/Stems or Marked with Black.Missouri Botanic Gardens Plants of Merit.Great Plant Picks for the Pacific Northwest.Sasanquas - Variegated and Multi-Colored.Fragrant Camellias, Sasanquas, and Hybrids.Dwarf Sasanqua Camellias (2 to 5 feet high).Cold Hardy Camellias for Zone 6A and 6B.Camellias - Midseason Flowering Japonicas.Camellias - Late Season Flowering Japonicas.Camellias - Exceptionally Long Flowering Japonicas.Camellias - Early Season Flowering Japonicas.Camellia Japonica By Flowering Season (Early-Mid-Late). ![]() ![]() ![]() ![]() Automatically calculates fetal heartrate and pulse. Built-in, dual speakers provide excellent sound quality in quiet or high-noise environments. All other listings have a 14 day return period for domestic buyers. Includes easy-to-use touchscreens and smart charging stand. No refunds or returns for international buyers or on parts/parts only units. The ImexDop CT+ from Nicolet is a portable counter-top Doppler that offers even more features than hand-held Dopplers. If the item is subject to FDA regulation, I will verify your status as an authorized purchaser of this item before shipping of the item." Nicolet Vascular Imexdop CT+ Doppler with 3 & 8 MHz probes (CT38+) - Preowned in Good Condition VENDOR DESCRIPTION. Natus IMEX DOP CT+ doppler with charging station This units smart charging stand can be mounted to the wall, counter or IV pole One system can be used for. If so, do not buy this item unless you are an authorized purchaser. Food and Drug Administration and state and local regulatory agencies. "The sale of this item may be subject to regulation by the U.S. Shipper is not responsible for any delays once the package leaves our facility. ImexDop CT ultrasonic Doppler auscultator (Nicolet Vascular, Madi- son, Wisconsin) was positioned di- rectly on the pseudoaneurysm model and was used to. Please be sure that the item that you are purchasing can be imported into your country. BEING SOLD AS IS ! BIOMED CHECK IS STRONGLY RECOMMENDED BEFORE CLINICAL USEīuyers are responsible for all customs charges inclusive of any and all taxes and duties. Natus Imex Doppler Accessories CB0046 - Elite Coiled Cord, Each 67.00 Natus Imexdop Ct+ Doppler System CTX0+ - Unit, No Probe, Each 780.00 Natus Imexdop Ct+ Doppler System CT22+ - Unit, Two 2 MHz Obstetric Probes, Each 1,150. THE ITEM HAS NOT BEEN TESTED TECHNICALLY OR PROFESSIONALLY AT OUR END UNABLE TO TESTING. Nicolet IMEX DOP CT Doppler With Charger. ![]() ![]() ![]() ![]() ![]() More defenses may be desirable to better protect Sanctuary from hostile attackers. The guard post is cheaper to build, but at least 3 are required and a settler must be assigned before they will contribute any defense. A single turret will provide enough defense rating to complete the quest.Unassigned settlers will typically assign themselves to tend crops, but this doesn't always happen, so it's a good idea to double-check. A settler also needs to be assigned for the crop to count towards the food supply. There are several crops behind the yellow house in the middle of Sanctuary that can be harvested to obtain the required materials. In order to plant crops, the Sole Survivor will need to obtain the associated food item.Water purifiers provide significantly more water, but must be placed in the river and require a power source. However, at least two are needed to complete the quest due to their low water output. You can also exchange coal and iron ingots. Water pumps are the easiest way to provide water early on, requiring only a bare patch of dirt. Armorer is a villager who sells armor and a shield, including enchanted diamond armor, in exchange for emeralds.The houses in Sanctuary that still stand can be used for this purpose, or the Sole Survivor can build their own using the workshop. When building beds, they must be inside a building to count towards the quest.After the final objective is complete, Sturges will thank the Sole Survivor, ending the quest. After completing each objective, the Sole Survivor will need to speak to Sturges again to receive the next one (even if they build everything ahead of time). As they build, the Pip-Boy will track their progress. The Sole Survivor will need to use the settlement workshop to build the appropriate settlement buildings to provide for each need. If they agree to help, Sturges will offer a series of four tasks to complete for the settlement: providing beds, water, food, and finally defenses for the people of Sanctuary. To start the quest, the Sole Survivor must talk to Sturges, who will ask if they're willing to do some work. Westminster Abbey, formally titled the Collegiate Church of Saint Peter at Westminster, is. After the Sole Survivor agrees (completing When Freedom Calls and beginning The First Step), Preston will mention that Sturges could use some help as well. Not to be confused with Westminster Cathedral or Westminster Chapel. Upon returning to Sanctuary Hills at the end of When Freedom Calls, Preston Garvey will approach the Sole Survivor and ask them to help rebuild the Minutemen. ![]() ![]() Auditioning for a part in More Than You Deserve, a production written by Michael Weller (who in 1979 would write the screenplay for the cinematic adaptation of Hair) and a New York native named Jim Steinman, Meat Loaf impressed. And then came the meeting that would change the trajectory of two names now as immortal as any that popular music has produced. He hired an agent, then re-joined the cast of Hair – this time on Broadway. Again he returned to the theatre, appearing in the original off-Broadway production of Rainbow at the Orpheum Theatre in New York City. Not only did the label misspell his name, but they later replaced his vocals on the song ‘Who Is The Leader of The People’ with those of rising soul great Edwin Starr. The lack of respect awarded to him continued. ‘Stoney & Meatloaf’ – and that is an album sleeve – arrived in late 1971. His performance in the hit hippie musical led to Motown inviting both himself and fellow cast member Shaun ‘Stoney’ Murphy to make a record. And yet – big boned, even bigger voice, once asked by a sound engineer: “Where did you learn to sing, son?” Step back a few feet and try it again?” – he felt his unique talents weren’t being taken seriously, so retreated to his first love, joining the LA cast of Hair. Upon relocating to Los Angeles, his first band Meat Loaf Soul opened for such rock‘n’roll luminaries as Van Morrison’s Them, Janis Joplin, The Who, and – get this! – The Stooges and MC5. ![]() Despite showing a flair for performance while at high school, appearing in theatre productions of Where’s Charley? and The Music Man, he once described his early days in the music industry as being defined by being treated like “a circus clown”. All rights reserved.Meat Loaf – who has passed away, aged 74 from complications due to COVID – would need his bulk to break down the obstacles that piled up in his way. The UK's Top 20 biggest debut albums of all time POS Listen to the countdown from 40-21 exclusively on BBC Sounds. ![]() Steve Wright will count down the full Top 20 on BBC Radio 2 this National Album Day, Saturday 15 October, from 1-3pm. Spice Girls come in at Number 6 with Spice (1996), the biggest debut for a group, while rounding out the Top 10 is Keane's Hopes and Fears (7), Jagged Little Pill by Alanis Morissette (8), Sam Smith's In The Lonely Hour (9) and Parachutes by Coldplay (10). See the full Top 20 below. ![]() ![]() I felt like I was representing my country and that felt amazing." "I had the most incredible support from the UK when I released my debut album Spirit." Lewis said, "I was overwhelmed with how much love it received and I just remember feeling the same then as I do now, endlessly thankful to everyone that listened and supported me. Leona Lewis follows at Number 3, scoring the biggest debut for a female artist with 2007's Spirit she's closely followed by Lady Gaga's The Fame (4), which sports two Number 1 singles in Just Dance and Poker Face, and Dido's 1999 album No Angel (5) which took 20 months to finally reach Number 1 in February 2001 before spending seven weeks at the top. Reacting to the news James said, “Are you sure? There must have been some kind of mistake.” MORE: The biggest debut albums from every UK region revealed Taking the Number 2 position, and the biggest debut album by a British artist, is none other than James Blunt with his 2004 chart-topping debut Back To Bedlam. It has spent a total of 530 weeks in the Official Albums Chart Top 100 in the 45 years since its release. Bat Out Of Hell reached the Top 10 for the first time in 2013 - proving the longevity of the collection, before it peaked at Number 3 in January this year following the sad news of Meat Loaf's death. ![]() ![]() ![]() The 24V Children Ride On Car Charger is UL-listed and BC certified, ensuring high-quality and safety standards. This feature allows for easy monitoring of the charging process, ensuring that your child's ride-on toy is always ready for action. The red light indicates that the battery is currently charging, while the green light indicates that the battery is fully charged. This charger features a special status light that indicates the charging status. This charger is designed to fit the MODEL 24-04-02E and is equipped with an AC input of 120V, 0.3A, and 50/60Hz output of 24V, 0.6A. The 24V Children Ride On Car Charger with B-Type Plug is the perfect solution for powering up your little one's ride-on toy. The durable construction and realistic quad styling guarantee that this vehicle will be a favorite toy for years to come. Whether your child wants to take a leisurely ride around the neighborhood, or experience the excitement of off-road adventure, this ride-on vehicle is sure to deliver. Safety is a top priority, so the vehicle includes a parent-controlled, high-speed lockout and Power-Lock brakes for added peace of mind. Not only is this ride-on vehicle designed for hard surfaces, but it also has the ability to drive on wet grass, ensuring that your child can enjoy the outdoors in any weather condition. Introducing the ride-on vehicle that boasts realistic quad styling and awesome graphics, perfect for adventurous little ones! With a maximum speed of 3 and 6 mph (4.8 and 9.6 km/h) in forward drive, and 3 mph (4.8 km/h) in reverse, this vehicle is designed to provide a thrilling ride for kids aged 3-7 years, with a maximum weight limit of 65 lbs (29.5 kg). Many parents might be asking themselves: what is the best 24 volt power wheels toy for my kids? Which features should I look for when choosing a power wheels toy? How long will the battery last? How fast does it go? How safe is it for my child to ride? Which brands are the most reliable? Keep reading to find out the answers to all your questions about the best 24 volt power wheels on the market and find the perfect toy for your little one. The battery life and the charging time should also be taken into account as this will determine how much time your kid can spend enjoying the ride before needing to recharge the battery. ![]() The type of terrain where the toy will be used is also an important factor to consider. First, it's important to choose the right size and weight capacity based on the child's age and weight. This amazing toy is powered by a 24-volt battery and offers a much faster and more thrilling ride than the typical 12-volt toys that usually don't deliver the same kind of excitement.īefore making any purchase, there are certain factors that readers need to consider. If you’re looking for a fun and exciting way to let your kids enjoy their playtime, 24 volt power wheels can be the perfect choice. ![]() ![]() ![]() ![]() This date is said to also mark when the Last Days began. The Holy Spirit is believed to be a force rather than a person.Ī significant underpinning belief of Jehovah’s Witnesses is that Jesus’ heavenly rule (or “heavenly Kingdom power”) began in 1914. Witnesses use the name “Jehovah” rather than “God,” and they focus their worship on Jehovah rather than on Jesus, whom they believe was Jehovah’s only direct creation. ![]() Members believe that only Jehovah’s Witnesses will be saved when most of the world’s population is killed at Armageddon. “They believe that the destruction of the present world system at Armageddon is imminent, and that the establishment of God’s kingdom on earth is the only solution for all problems faced by humankind.”. The leadership predicted and believe that the end of the world is soon to come. They believe that Christ died for the sins of man, but that he was resurrected spiritually rather than physically. For example, they believe that God is one person, not a trinity. Since the inception in 1879 of what is now known as the Watchtower Bible and Tract Society, its adherents, called Jehovah’s Witnesses, have had distinctive beliefs that separate them from mainstream Christianity. The Beliefs and Practices of Jehovah’s Witness ![]() ![]() Whilst fires in thatched buildings are not the norm, research has shown that the major cause of fires in thatched buildings is heat transfer from the chimney into the thatch. Thatched properties come with a slightly higher cost of insurance due to a higher fire risk, they also have a more expensive rebuild value than conventional houses because they’ve been built using specific materials by specialists, there are only 800 master thatchers in the country after all! That being said, whilst there are specialist insurance companies you can go for, such as the NFU, many standard home insurance companies will still offer you a policy. It’s important to have your roof inspected regularly, just like you would your boiler or car, the better maintained you keep it, the longer it will last! Insurance The ridge of a thatch needs replacing every 10-15 years, this costs usually £150-£200 per foot. Thatched roofs need maintenance, even after a new thatch has been put on. The cost includes sourcing the materials and the labour involved in putting it all together. It’s important to note each thatcher is different and therefore prices will vary. Thatches will usually charge by the square (10 ft × 10 ft) so if you’re looking for ball-park figures and a rough estimate, an average price would be about £700 per square. Water reed thatch should last at least 30 years, but often 40-50 years, and sometimes longer! This is the longest-lasting type of thatched roof. Water Reed – Water reed is a wetland plant, which was historically maintained to provide for thatching purposes. ![]() Combed wheat reed thatched roofs should last upwards of 30 years. It is known as reed because of its similarity to water reed in appearance and in the way it is laid on the roof. Long straw thatched roofs will last around 20-30 years.Ĭombed Wheat Reed – As with long straw, this type of thatch is based on cereal straw, usually wheat. Long Straw – Once the most common type of thatch in the UK, the basic material for long straw is a cereal straw, usually wheat but sometimes rye. ![]() The straw you see on top of these houses weren’t just plonked there in the 1700s, it has to be redone every few decades! There are a number of different types of thatches and this will dictate how often you will need to fork out for a new one. In 1800 there were approximately 950,000 thatched buildings in England, but by 1960 this number had dropped to 35,000. ![]() Sadly, from the start of the 19th Century, there was a steep decline in the number of thatched buildings. The word ‘thatch’ is Anglo-Saxon in origin and simply meant roof covering, it is thought to be one of the oldest building techniques in the world and there is no surprise that East Anglia, home to the Anglo Saxons, is covered in thatched buildings. ![]() Hopefully, this article will help you decide whether you do or don’t want a thatched roof and if you do, it’ll guide you on all the things you need to look out for! Thatched cottages look lovely, don’t they? And they are! But before you plunge into buying one, there are a lot of things you need to know! I am currently on the hunt for a period property in the UK to buy and turn into my very own home and my heart is currently set on a 3 bedroom thatch. ![]() |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |